Heart cell coupling and impulse propogation [sic] in health and disease by Walmor C. De Mello

Cover of: Heart cell coupling and impulse propogation [sic] in health and disease | Walmor C. De Mello

Published by Kluwer Academic Pub. in Boston .

Written in English

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Subjects:

  • Heart cells.,
  • Heart -- Pathophysiology.,
  • Cell interaction.,
  • Connexins.,
  • Gap junctions (Cell biology),
  • Cardiovascular Physiology.,
  • Cell Communication.,
  • Connexins.,
  • Gap Junctions.

Edition Notes

Includes bibliographical references and index.

Book details

Other titlesHeart cell coupling and impulse propagation in health and disease
Statementby Walmor C. De Mello and Michiel J. Janse.
SeriesBasic science for the cardiologist -- 12
ContributionsJanse, Michiel Johannes.
Classifications
LC ClassificationsQP114.C44 D43 2002
The Physical Object
Paginationxiii, 470 p. :
Number of Pages470
ID Numbers
Open LibraryOL19288443M
ISBN 101402071825
LC Control Number2002030076

Download Heart cell coupling and impulse propogation [sic] in health and disease

Heart Cell Coupling and Impulse Propagation in Health and Disease includes an up-to-date review on how heart cells communicate and impulse propagation under normal as well as under pathological conditions. The complexity of intercellular coupling and impulse propagation is discussed, providing the reader with a broad view of the importance of these processes and how they contribute to the Manufacturer: Springer.

Heart Cell Coupling and Impulse Propagation in Health and Disease includes an up-to-date review on how heart cells communicate and impulse propagation under normal as well as under pathological conditions. The complexity of intercellular coupling and impulse propagation is discussed, providing the reader with a broad view of the importance of these processes and how they contribute to the Format: Hardcover.

Heart Cell Coupling and Impulse Propagation in Health and Disease includes an up-to-date review on how heart cells communicate and impulse propagation under normal as well as under pathological conditions. The complexity of intercellular coupling and impulse propagation is discussed, providing the.

Heart Cell Coupling and Impulse Propagation in Health and Disease includes an up-to-date review on how heart cells communicate and impulse propagation under normal as well as under pathological conditions.

The complexity of intercellular coupling and impulse propagation is discussed, providing the reader with a broad view of the importance of these processes and how they contribute to the. De Mello W.C. () Cell Coupling and Impulse Propagation in the Failing Heart:The Role of the Renin Angiotensin System.

In: Heart Cell Coupling and Impulse Propagation in Health and Disease. Basic Science for the Cardiologist, vol Cited by: 2. Heart Cell Coupling and Impulse Propagation in Health and Disease includes an up-to-date review on how heart cells communicate and impulse propagation under normal as.

Basic Mechanisms of Cardiac Impulse Propagation and Associated Arrhyth-mias. Physiol Rev –, ; /physrev—Propagation of excitation in the heart involves action potential (AP) generation by cardiac cells and its propagation in Cited by: Basic Mechanisms of Cardiac Impulse Propagation and Associated Arrhythmias Article Literature Review in Physiological Reviews 84(2) May with Reads How we measure 'reads'.

Heart failure (HF) is a heterogeneous clinical syndrome which may be characterized by a variety of phenotypic changes, many of which have been linked to abnormalities in the intracellular calcium(Ca2+) signal. These range from mechanical dysfunction, usually characterized by reduced systolic contractile function, to electrophysiological dysfunction including QT interval prolongation, an.

Perturbation of cell-cell coupling and NaD ion channels Reduction in cellular coupling was done by acute treatment with very low doses of heptanol (Sigma-Aldrich, St. Louis, MO). Heptanol was diluted in Tyrode’s solution to and mM, and at each concentration samples were perfused for 10 min before measurements.

Increase in cellular. Introduction. It is well known that the heart depends on electrical depolarization to trigger mechanical contraction, but mechanical perturbations have also long been seen to affect cardiac electrophysiology [1,2].The process by which myocyte electrical activation leads to mechanical contraction is known as excitation–contraction coupling (ECC), while the process by which a mechanical Cited by: Heart Failure as a Progressive Model.

Figure 1 provides a general conceptual framework for discussing the development and progression of heart failure. As shown, heart failure may be viewed as a progressive disorder that is initiated after an “index event” either damages the heart muscle, with a resultant loss of functioning cardiac myocytes, or alternatively disrupts the ability of the Cited by: This chapter discusses the role of cell coupling in developing systems— that is, the heart-cell paradigm.

The embryonic heart cells, because of their spontaneous electrical activity and contractility, provide unique advantages as a model system for the analyses of cellular by:   The role of ventricular–arterial coupling in cardiac disease and heart failure: assessment, clinical implications and therapeutic interventions.

A consensus document of the European Society of Cardiology Working Group on Aorta & Peripheral Vascular Diseases, European Association of Cardiovascular Imaging, and Heart Failure Association.

Ventricular–arterial coupling in valvular heart disease Aortic stenosis In patients with aortic stenosis (AS), the left ventricle is often facing a double load: a valvular load imposed by AS and an arterial load caused by a decrease in systemic arterial compliance (or an increase in systemic vascular resistance) in the context of existing co Cited by: Antiplatelet and Anticoagulant Agents in Heart Failure Current Status and Future Perspectives Paul A.

Gurbel, MD, Udaya S. Tantry, PHD Baltimore, Maryland There has been a 3-fold increase in hospital discharges for heart failure (HF) and also significantly increased mortality rate in HF patients in Cited by: Get this from a library.

Heart Cell Coupling and Impulse Propagation in Health and Disease. [Walmor C Mello; Michiel J Janse] -- Heart Cell Coupling and Impulse Propagation in Health and Disease includes an up-to-date review on how heart cells communicate and impulse propagation under normal as well as under pathological.

Adhesion between cardiac myocytes is essential for the heart to function as an electromechanical syncytium. Although cell-matrix and cell–cell adhesions reorganize during development and disease, the hierarchical cooperation between these subcellular structures is poorly understood.

We reasoned that, during cardiac development, focal adhesions mechanically stabilize cells Cited by: 1. Introduction. Heart failure is accompanied by changes in the ventricular action potential (AP) in both animal models and patients with heart ially, three phases are altered during the time course of the AP: (i) the amplitude of the fast upstroke is increased, (ii) the fast early repolarisation phase (or notch) is absent or diminished, and (iii) the AP is prolonged.

the electrical stability of the heart (Teunissenet al. Fontes et al. A hallmark of the electrical changes with regard to impulse conduction is an impairment of electrical coupling due to abnormal expression of Cxconstituted gap junctions. Available data suggest that particularly spatial heterogeneity and severity of Cx ISCHEMIC HEART DISEASE ISCHEMIC HEART DISEASE (IHD) CORONARY HEART DISEASE (CHD) CORONARY ARTERY DISEASE (CAD) ATHEROSCLEROTIC HEART DISEASE (ASHD) Synonymous terms referring to syndromes resulting in and from myocardial ischemia.

All ways of saying there is compromise of blood flow and oxygen to the myocardium. Restoring heart function and electrical integrity: closing the circuit discs may actively influence cell–cell impulse channels in health and disease.

Heart Rhythm 7, – ( Cited by: Table of contents for Heart cell coupling and impulse propogation [sic] in health and disease / by Walmor C. De Mello and Michiel J. Janse. Bibliographic record and links to related information available from the Library of Congress catalog. Most treatment for heart failure can only slow it down or ease your symptoms.

Soon, it may be possible to fix what causes it. Doctors are testing whether stem cells can repair or replace damaged. Heart cell coupling and impulse propogation [sic] in health and disease.

05/ May Control of the cardiovascular and respiratory systems in health and disease. 05/ texts. eye 0 Posts by stationcebu. Subject: Poster. Kléber, André G., and Yoram Rudy. Basic Mechanisms of Cardiac Impulse Propagation and Associated Arrhythmias. Physiol Rev –, ; /physrev—Propagation of excitation in the heart involves action potential (AP) generation by cardiac cells and its propagation in the multicellular tissue.

AP conduction is the outcome of complex interactions between cellular Cited by: Key steps in cardiac excitation-contraction coupling: Action potentials traveling along the sarcolemma and down into the transverse tubule (T-tubule) system depolarize the cell membrane.

Voltage-sensitive dihydropyridine (DHP) receptors (L-type calcium channels) open to permit calcium entry into the cell during phase 2 of the action potential. A siderophage is a hemosiderin-containing macrophage. Heart failure cells are siderophages generated in the alveoli of patients with left heart failure or chronic pulmonary edema, when the high pulmonary blood pressure causes red cells to pass through the vascular wall.

Siderophages are not specific of heart failure. They are present wherever red blood cells encounter macrophages. Heart failure epidemiology, ageing and disease progression. Symptomatic heart failure (HF) is a leading cause of morbidity with a high prevalence and mortality. From age 40 years onwards, the lifetime risk of developing HF is high.

Furthermore, ageing is increasingly recognized as an important risk factor for HF (Strait & Lakatta, ).Cited by: Implantable devices have been used for decades to treat heart first pacemaker was implanted over 40 years ago, and implantable defibrillators were first used in the early s.

But. Read the entire chapter on stem cell therapy for heart failure from Dr. Riordan’s book For more detailed information about our heart failure treatments, we welcome you to read/download the entire chapter on stem cell therapy for heart failure from Dr.

Riordan’s new book, Stem Cell Therapy: A Rising Tide – How Stem Cells are Disrupting. Understanding how different heart cells work together Regulation of cardiac excitation-contraction coupling by human cardiac fibroblasts in health and disease (Mr Brian Wang) Cesare M N Terracciano (lead researcher) Imperial College London.

Start date: 05 December (Duration 3 years). Heterogeneous Cell Coupling in the Heart An Electrophysiological Role for Fibroblasts Peter Kohl T he heart is a muscle. Muscles are made up of myo-cytes. These may differ in form and function, but—in coupling for impulse conduction via nonmyocytes by show-ing that replacement of HeLa-Cx43 with wild-type cells.

Heart cells of the tunicate, Chelyosoma, were found to be electrically coupling ratio in cells adjacent to the polarized cell was 40%. Electrical current generated by an impulse was observed to spread through an area of local conduction block caused by an overstretched by: 7.

Introduction. In the acute stage of a myocardial infarction loss of the gap junction protein connexin43 (Cx43) occurs contributing to slowed conduction and reentrant arrhythmias (Gutstein et al., ; Kieken et al., ).The mechanisms, by which Cx43 channels are lost, include the alteration of protein-partners of Cx43 (Kieken et al., ).

Madonna, R. et al. Position paper of the European society of cardiology working group cellular biology of the heart: cell-based therapies for myocardial repair and regeneration in ischemic heart. study Material, lecturing Notes, assignment, reference, wiki, description, explanation, brief detail and important questions and answers Important Que.

Despite major improvements in the treatment of virtually all cardiac disorders, heart failure (HF) is an exception, in that its prevalence is rising, and only small prolongations in survival are occurring.

An increasing fraction, especially older women with diabetes, obesity, and atrial fibrillation exhibit HF with preserved systolic function. The heart is a muscular pump connected to the systemic and pulmonary vascular systems. Working together, the principle job of the heart and vasculature is to maintain an adequate supply of nutrients in the form of oxygenated blood and metabolic substrates to all of the tissuesFile Size: KB.

Interpretation of pressure and CO measurements is aided by a consideration of the interaction or coupling between the heart and the vascular system.

This can be performed at the arterial side (ventriculo-arterial coupling) for arterial pressures, or on the venous side of the heart (ventriculovenous coupling) for CVP. Gap Junctions (Cell-to-Cell Conduction) In the heart, cardiac muscle cells (myocytes) are connected end to end by structures known as intercalated disks.

These are irregular transverse thickenings of the sarcolemma, within which there are desmosomes that hold the cells together and to. Ap -- Injecting stem cells into injured heart muscle seems to improve heart function -- and could mean a new treatment for congestive heart Author: Jeanie Lerche Davis.In physiology, an action potential occurs when the membrane potential of a specific cell location rapidly rises and falls: this depolarization then causes adjacent locations to similarly depolarize.

Action potentials occur in several types of animal cells, called excitable cells, which include neurons, muscle cells, endocrine cells, glomus cells, and in some plant cells.

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